Quick Answer: Hmg-coa Reductase Inhibitors (statins) Are Classified As Which Pregnancy Category?

What pregnancy category is statin?

The Food and Drug Administration (FDA) in the United States has designated all statins category X, which means their use during pregnancy is contraindicated. This determination is based on the overarching concept that the benefits of statin therapy during pregnancy do not outweigh potential fetal risks of exposure.

What category is statin drugs?

The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum low-density lipoprotein cholesterol concentrations.

Are statins teratogenic?

Our findings show no clear relationship of congenital anomalies with statin use in pregnancy, and our study supports the findings that statins are probably not teratogenic. However, until more information is available, statins should still be avoided in pregnancy.

Which one is the HMG-CoA reductase inhibitors?

These drugs, which include pravastatin, fluvastatin, atorvastatin, simvastatin and rosuvastatin, are the mainstay of therapy for elevated LDL cholesterol and both primary and secondary prevention of acute coronary syndrome and stroke.

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Can statins be continued in pregnancy?

The U.S. Food and Drug Administration (FDA) says that statins are not recommended for pregnant women. They are rated as “Pregnancy Category X” drugs, which signifies that studies have shown they may cause birth defects and that the risks clearly outweigh any benefit.

Is statin safe in pregnancy?

Statins are safe to use if you are not pregnant but can become pregnant. If you are taking a statin before you know you are pregnant, it is unlikely to harm your unborn baby.

Why you should never take statins?

Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins.

Do statins clear the arteries of plaque?

Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.

Do statins make you age faster?

So, while these findings are interesting and potentially important, there’s quite a large leap from these studies of minced fat cells to the conclusion that being treated with statins will lead a person to age prematurely.

Can Atorvastatin cause miscarriage?

Does taking a statin increase the chance for miscarriage? Miscarriage can occur in any pregnancy. Most studies have not found a higher chance of miscarriage in people taking statins during pregnancy.

Why are statins contraindicated in pregnancy?

Cholesterol is known to be essential for fetal development. Statins, which inhibit cholesterol production, have therefore been considered as potential teratogens and are contraindicated in pregnancy.

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Are statins teratogenic in humans addressing the safety of statins in light of potential benefits during pregnancy?

Statins are contraindicated during pregnancy based on the overarching concept that their benefits do not outweigh potential fetal risks of exposure. The role of cholesterol during gestation, combined with teratogenic effects seen in animal testing of lovastatin has supported this contraindication.

What is the another name of HMG Co A inhibitor?

HMG-CoA reductase inhibitor drugs are called statins. Also called hydroxymethylglutaryl-coenzyme A reductase inhibitor.

What is a common side effect of HMG-CoA reductase inhibitors?

The most common side effects of HMG-CoA reductase inhibitors include: Muscle aches, tenderness, or weakness (myalgia) Drowsiness. Dizziness.

What is the function of HMG reductase?

HMG-CoA Reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.

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